α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96 A potential therapeutic target for cancer metastasis

Background: Integrins are chaperoned by gp96, but the binding region to gp96 remains unknown. Results: Deletion of α7 helix from αI domain of integrin abolished the interaction between integrin and gp96. Targeting this region by corresponding peptide blocked cell invasion. Conclusion: We successfully mapped the binding region of integrin to gp96. Significance: This study will facilitate the development of new cancer therapeutics.