Protective Effects of Dietary Pulse Flours on the Transgenerational Influence of Maternal Obesity

PROTECTIVE EFFECTS OF DIETARY PULSE FLOURS ON THE TRANSGENERATIONAL INFLUENCE OF MATERNAL OBESITY - OUR LONG-TERM GOAL IS TO CHARACTERIZE THE INFLUENCE OF MATERNAL PULSE FLOUR CONSUMPTION, SOURCED FROM YELLOW PEAS, LENTILS, NAVY AND PINTO BEANS, AS A MEANS TO IMPROVE MATERNAL HEALTH AND PREVENT NEGATIVE OFFSPRING HEALTH OUTCOMES IN OBESE PREGNANCIES. THIS PROJECT HAS TWO OBJECTIVES THAT WILL BE PURSUED USING A DIET-INDUCED OBESE SPRAGUE DAWLEY RAT MODEL. OBJECTIVE 1. CHARACTERIZE THE PROTECTIVE INFLUENCE OF DIETARY PULSE FLOUR CONSUMPTION ON MATERNAL OBESITY AND FETAL HEALTH; AND OBJECTIVE 2. EVALUATE THE INFLUENCE OF MATERNAL PULSE CONSUMPTION DURING PREGNANCY AND LACTATION IN PROTECTING AGAINST OBESITY AND OBESITY-INDUCED GUT MICROBIOME DYSBIOSIS IN OFFSPRING THROUGHOUT THE LIFE-COURSE.