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Dive into the research topics where Fraser Sim is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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EDI - Investigate the role of EDI-298 in the cuprizone model of demyelination
Sim, F. (PI)
02/2/26 → 01/31/27
Project: Research
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Molecular Mechanisms and Therapeutic Potential of Heparan Sulfate Proteoglycans in Remyelination
Sim, F. (PI), Paez, P. (CoI), Feltri, M. (CoI) & Xu, D. (CoI)
US Army Medical Research Acquisition Activity
07/1/23 → 06/30/27
Project: Research
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Programmable hydrogels for optimized human oligodendrocyte transplantation in demyelinating disease
Andreadis, S. (PI), Cheng, C. (CoI) & Sim, F. (CoI)
National Inst of Neurological Disorders & Stroke
07/1/23 → 06/30/28
Project: Research
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Parsing the central control of thirst and hunger using a rat model of diabetes insipidus
Daniels, D. (PI), Paul, M. (CoI), Sim, F. (CoI) & Xu-Friedman, M. (CoI)
National Inst of Diabetes Digestive Kidney Disease
05/1/22 → 05/31/27
Project: Research
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Investigating the role of novel p38 gamma inhibitors on human OPC differentiation in vitro
Sim, F. (PI)
03/18/25 → 03/17/26
Project: Research
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Clemastine Induces Oligodendrocyte Progenitor Pool Exhaustion and Senescence in the Context of Chronic Demyelination in a Rabbit Model
Cooper, J. J. M., Muthaiah, R., Frost, J. R., Buck, G. T., Ravichandar, R., Gadelkarim, F., Raymond, F. D. & Sim, F. J., Jan 2025, In: Annals of Neurology. 97, 1, p. 116-133 18 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells
Weaver, M. R., Shkoruta, D., Pellegatta, M., Berti, C., Palmisano, M., Ferguson, S., Hurley, E., French, J., Patel, S., Belin, S., Selbach, M., Paul, F. E., Sim, F., Poitelon, Y. & Feltri, M. L., Mar 25 2025, In: Cell Reports. 44, 3, 115401.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination
Ravichandar, R., Gadelkarim, F., Muthaiah, R., Glynos, N., Murlanova, K., Rai, N. K., Saraswat, D., Polanco, J. J., Dutta, R., Pal, D. & Sim, F. J., Jul 10 2024, In: Journal of Neuroscience. 44, 28, e0051242024.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease
Evans, L. M. P., Gawron, J., Sim, F. J., Feltri, M. L. & Marziali, L. N., Dec 2024, In: PLOS ONE. 19, 12 December, e0314858.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Injectable shear-thinning hydrogels promote oligodendrocyte progenitor cell survival and remyelination in the central nervous system
Podder, A. K., Mohamed, M. A., Seidman, R. A., Tseropoulos, G., Polanco, J. J., Lei, P., Sim, F. J. & Andreadis, S. T., Jul 2024, In: Science Advances. 10, 28, adk9918.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations