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Dive into the research topics where Amanda Klein is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Grants & Projects
- 1 Active
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KATP Channels as Downstream targets of adenylyl cyclases during opioid tolerance and withdrawal
Klein, A. (PI)
National Institute on Drug Abuse
11/1/23 → 05/31/27
Project: Research
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Ca2+/calmodulin-dependent inhibitors of adenylyl cyclase 1 as novel nonopioid analgesics for chronic inflammatory pain
Dwyer, T. S., Shrinidhi, A., Aryal, S., Berchtold, M. W., Munk, M., Klein, A. H., Koss, W. A., Flaherty, D. P. & Watts, V. J., May 1 2026, In: Molecular Pharmacology. 108, 5–6, 100121.Research output: Contribution to journal › Article › peer-review
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Inhibition of adenylyl cyclase 1 or exchange protein activated by cAMP restores ATP-sensitive potassium channel activity after chronic opioid exposure
Klein, A. H., Alam, S. M. S., Johnson, K., Kriner, C., Beck, B., Nelson, B., Hill, C., Meyer, B., Mellang, J. & Watts, V. J., Jul 2026, In: British Journal of Pharmacology. 183, 13, p. 3706-3722 17 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain
Martin, M. K., Rodriguez, R., Guerrero, G., Sheehan, G. D., Powell, R., Klein, A. H. & Bhattacharjee, A., May 1 2025, In: Pain. 166, 5, p. 1191-1203 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Loss of ATP-Sensitive Potassium Channel Expression and Function in the Nervous System Decreases Opioid Sensitivity in a High-Fat Diet–Fed Mouse Model of Diet-Induced Obesity
Fisher, C., Johnson, K., Moore, M., Sadrati, A., Janecek, J. L., Graham, M. L. & Klein, A. H., Aug 2024, In: Diabetes. 73, 8, p. 1244-1254 11 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine-Induced Hypersensitivity, and Precipitated Withdrawal in Mice
Doucette, A., Johnson, K., Hulke, S., Mujteba, S., Miller, E., Meyer, B., Dosa, P. I. & Klein, A. H., Oct 1 2023, In: Journal of Pharmacology and Experimental Therapeutics. 387, 1, p. 18-26 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations