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Alex Vecchio

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Alex Vecchio

Assistant professor (hs)

    20102025

    Research activity per year

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    • Biophysical basis of tight junction barrier modulation by a pan-claudin-binding molecule

      Ogbu, C. P., De Las Alas, M., Mandriota, A. M., Liu, X., Kapoor, S., Choudhury, J., Ruma, Y. N., Goodman, M. C., Sanders, C. R., Gonen, T., Kossiakoff, A. A., Duffey, M. E. & Vecchio, A. J., Jun 1 2025, In: PNAS Nexus. 4, 6, pgaf189.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • One-shot design of functional protein binders with BindCraft

      Pacesa, M., Nickel, L., Schellhaas, C., Schmidt, J., Pyatova, E., Kissling, L., Barendse, P., Choudhury, J., Kapoor, S., Alcaraz-Serna, A., Cho, Y., Ghamary, K. H., Vinué, L., Yachnin, B. J., Wollacott, A. M., Buckley, S., Westphal, A. H., Lindhoud, S., Georgeon, S. & Goverde, C. A. & 9 others, Hatzopoulos, G. N., Gönczy, P., Muller, Y. D., Schwank, G., Swarts, D. C., Vecchio, A. J., Schneider, B. L., Ovchinnikov, S. & Correia, B. E., Oct 9 2025, In: Nature. 646, 8084, p. 483-492 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      106 Scopus citations

    • Structures of a synthetic antibody selected against and bound to the C-terminal domain of Clostridium perfringens enterotoxin

      Ogbu, C. P., Goldbach, N. M., Pacesa, M., Kapoor, S., Correia, B. E. & Vecchio, A. J., Oct 2025, In: Protein Science. 34, 10, e70281.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Computational design of soluble and functional membrane protein analogues

      Goverde, C. A., Pacesa, M., Goldbach, N., Dornfeld, L. J., Balbi, P. E. M., Georgeon, S., Rosset, S., Kapoor, S., Choudhury, J., Dauparas, J., Schellhaas, C., Kozlov, S., Baker, D., Ovchinnikov, S., Vecchio, A. J. & Correia, B. E., Jul 11 2024, In: Nature. 631, 8020, p. 449-458 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      80 Scopus citations

    • Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4

      Rathnayake, S. S., Erramilli, S. K., Kossiakoff, A. A. & Vecchio, A. J., Nov 7 2024, In: Structure. 32, 11, p. 1936-1951.e5

      Research output: Contribution to journal › Article › peer-review

      Open Access
      9 Scopus citations
    View all 22 Research outputs